In this episode of Timepie Lecture Series, our guest is Professor Joseph Baur from University of Pennsylvania.
He serves as the Director of Mouse Phenotyping, Physiology, and Metabolism Core of Diabetes Research Center. His work is centered on elucidating the molecular mechanism(s) that mediate improvements in health and delays in multiple age-related diseases, with a particular focus on nicotinamide adenine dinucleotide (NAD+) metabolism and mTOR signaling. Click the link to get to the homepage of his lab: https://www.med.upenn.edu/baurlab/people.html
0:00 Introduction
4:10 What is NAD+
06:14 History of NAD+ discovery
09:10 Functions of NAD+
11:20 Molecular mechanism and synthesis pathway of NAD+
14:01 Pre-clinical studies of NAD+ precursors
19:36 Clinical studies of NAD+ precursors
24:06 Outstanding questions in NAD+ research
32:49 Metabolism of NAD+
52:22 Conclusions
53:19 Personal habits and feelings of supplementing NAD+ precursors
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