Dominic D’Agostino, Ph.D., has maintained involvement in a vast array of professional, academic, and personal endeavors. As an Associate Professor with tenure at the University of South Florida, Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology, with a focus on such topics as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health, and resilience of the warfighter and astronaut. The main focus of his lab over the last 10 years has been understanding the anticonvulsant and neuroprotective mechanism of the ketogenic diet and ketone metabolite supplementation.
This episode is hosted by Dr. Shawn Baker MD. Find him at https://shawn-baker.com
Timestamps
00:00 Research and ongoing clinical trial
04:53 How many cows does Dominic have?
09:19 Inflammation, neuro-inflammation
12:48 Chronic ketosis
17:13 Ketone disposal
20:17 Low blood glucose in context of ketogenic diet
23:09 Brain consumer of ketones
24:57 Metabolic flexibility
28:31 Facilitating ketosis in metabolically resistant people
31:01 Gluconeogenesis
34:15 Is there a deleterious effect to relying on carbs ingested?
35:35 Hypoketotic and hypoglycemic
38:05 The dose makes the poison
40:19 Circadian timing of meals
43:43 Traumatic brain injury
47:23 Cancer and ketogenic diets
52:21 Gut permeability
55:19 Calorie restricted diets vs ketogenic diets
57:30 Higher protein diets in the context of cancer or aging
59:25 Longevity vs function
61:40 Experiments on lab rats
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