Dr Michael Zemel presents about leucine is the direct activator of SIRT1 and SIRT3. Leucine also amplifies the effect when it combines with resveratrol, metformin and NAD boosters like NMN & NR.
Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span
https://www.liebertpub.com/doi/10.1089/jmf.2020.0105
Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes
https://www.hindawi.com/journals/jnme/2014/239750/
Synergistic effects of metformin, resveratrol, and hydroxymethylbutyrate on insulin sensitivity
Michael Zemel, PhD, is founder and CSO of NuSirt Biopharma, where he leads research programs focused on energy-sensing and development of therapeutics for diseases of aging and over-nutrition. Previously, he was Professor of Nutrition and of Medicine at the University of Tennessee from 1990-2012, where his work focused on energy sensing, muscle-fat crosstalk, and regulation of adipocyte metabolism. Prior to the University of Tennessee, he served on the faculties of Endocrinology and of Nutrition at Wayne State University and as Research Endocrinologist at the VA Medical Center associated with Wayne State from 1980-1990, where his work focused on endocrine regulation of cell signaling and downstream effects on both blood pressure regulation and insulin sensitivity. Dr. Zemel received his PhD in Physiology and Nutrition at the University of Wisconsin-Madison.
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DISCLAIMER: Please note that none of the information in this video constitutes health advice or should be substituted in lieu of professional guidance. The video content is purely for informational purposes.
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