You asked. I deliver. So i recently spoke with Dr Brandon Berry about his work using the tool mitochondria-ON. Here, i will explain how this works
In our cells, we have organelles, you have likely heard of called mitochondria. Primarily these organelles are responsible for the generation of ATP. The way ATP is generated is through the generation of a proton motive force – essentially a high concentration of protons – hydrogen ions – in the space between the membranes of this organelle. When these protons move down their concentration gradient out of the space between the membranes they go through a protein called ATP synthase. The movement of protons through this protein facilitates the generation of ATP – the energy source of the cell. Mitochondria-ON, is a tool that also moves protons across the membrane. But it can only do this is the presence of a cofactor – all-trans-retinal and light. In this paper, Brandon activated this tool using light during adulthood of the worms – so it kept this high proton motive force. He showed it extended their lifespan. Listen to our full conversation here; https://youtu.be/twke5yKQbvk
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