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Mitochondrial DNA is replicated independently of the nuclear DNA. But mitochondria depends on the proteins made from the information in nuclear DNA. It replicates via D loop formation through a strand displacement mechanism initiated at OriH. The helicase TWINKLE and DNA Polymerase Gamma drive the initiation of the major arc, which activates the OriL through a stem loop structure. Finally, DNA polymerase circles back to the origin and terminates replication. While this sounds simple, many aspects of the mtDNA replication are not clearly understood – this video discussion also highlights the many gaps in our knowledge concerning mtDNA replication.
Jump to your favorite section:
00:00 mtDNA structure
02:43 mtDNA enzymes
04:37 mtDNA replication
05:58 OriH initiation
09:42 D-loop regulation
11:44 OriL initiation
14:22 OriL termination
15:19 OriH termination
Patreon Page: https://www.patreon.com/the_Crux
Complete DNA Replication playlist: https://youtube.com/playlist?list=PL0Ymnd-zt4IgLefDaeqicJbCBnbLqnDJ7
*Must watch playlists*
All videos on DNA Replication: https://youtube.com/playlist?list=PL0Ymnd-zt4IgLefDaeqicJbCBnbLqnDJ7
All videos on Transcription: https://www.youtube.com/playlist?list=PL0Ymnd-zt4Ij2VcAOHNUweftSElVsc-MX
All videos on Translation: https://www.youtube.com/playlist?list=PL0Ymnd-zt4IjAAAMlPLDIXbs692Yp14xa
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