Monday, May 20, 2024
Mitochondrial Health

Prevent Muscle Loss and Improve Mitochondrial Health | Nicolas Verhoeven



Nicolas Verhoeven is a PhD Candidate in Molecular Medicine who works in a mitochondria and autophagy laboratory; he also holds a Masters in Exercise Physiology. Verhoeven runs Physionic, a brand that bridges the gap between scientific studies and the public’s understanding by opening studies, showing and explaining the data, and explaining the physiology that underlies that data. One of his missions is to improve the public’s understanding of the scientific literature without sacrificing the details (or the fun!).

In this episode we discuss:
– How to improve your mitochondrial health.
– The best skin supplements.
– Common misconceptions about Autophagy and how to trigger it.
– Which forms of training increase muscular power?

Chapters:
00:00:00 – Introduction
00:04:58 – Molecular Medicine
00:10:19 – The Relationship Between Aging and Power
00:15:57 – The Role of Muscle Denervation in Power Decline
00:21:19 – The Impairment of Mitochondria in Sarcopenia
00:26:30 – Exercise for Mitochondrial Health
00:32:00 – The Importance of Healthy Mitochondria
00:37:01 – Autophagy and Mitophagy
00:42:16 – Autophagy and Cancer
00:47:18 – Blood Work for Overall Health
00:52:25 – Effects of Exercise on Fiber Types
00:57:30 – The Neuromuscular Junction and Power Output
01:02:29 – Creatine for Brain Health
01:07:33 – Improved Insulin Resistance in Older Individuals
01:12:37 – Collagen Peptides
01:17:31 – Inexhaustible Curiosity in Science

This episode is brought to you by Thesis, Timeline Nutrition, Inside Tracker, 1stPhorm

Physionic YouTube – https://www.youtube.com/@Physionic/
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Physionic – https://www.physionic.org/

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35 thoughts on “Prevent Muscle Loss and Improve Mitochondrial Health | Nicolas Verhoeven
  1. Hi everyone, wanted to address two questions I saw pop up a lot when the audio version released:

    1. Does Creatine hurt your healthy kidneys?

    It’s true that creatine increases blood creatinine, and creatinine is a proxy measure of kidney health. However, creatinine can be elevated due to three primary reasons – 1. Actual kidney disease, 2. Creatine consumption, and 3. High muscularity. Only one of them is a legitimate concern (the obvious one). Also, a physician might point to your eGFR marker, but that marker is a calculation based on creatinine, so it too can lead to misdiagnosis. If you’re worried, you’d want to look at direct kidney tests like protein numbers, kidney proteins, and so on (talk to your nephrologist). I’m covering a few studies on creatine and kidney health soon – they all indicate it’s fine for healthy kidneys. Also, the National Institute of Diabetes and Digestive and Kidney diseases acknowledges all the above points – check out their website.

    2. What age for creatine on the brain?

    Studies only looked at 60+ years old, but it wouldn’t surprise me if results were seen in 50+, and maybe younger.

    Thank you for having me on, Dr. Lyon!

  2. Good grief. I had bought some
    Curcumin because it’s supposed to be good for reducing inflammation. Then yesterday I watched a video from Dr Wi Who said to stay away from it because of its high oxalates. 🤦‍♀️
    driving me crazy. LOL
    Also, I was taking creatine about 10 years ago and I noticed my blood sugars were constantly around 30mg/dl higher every day. So I stopped taking it.
    1.5 LADA

  3. I was diagnosed in 1990 ( age: 28) while in Army with mitochondria transport deficiency since I had a peak and subsequent decline in lactate transport were abnormally delayed suggesting a defect in lactate transport or in mitochondrial phosphorylation or in electron transport. ( had two muscle biopsies) Initially I was in the ER and admitted at Walter Reed with a CPK at 21,000. Per doctors I did not have an heart attack. Dr. Fishbein at NIH felt that I might be missing a mitochondrial enzyme. Yes, I have the detailed 3 page letter which is more in depth. I am taking CoQ10 and vitamin D3. I am 61 and I workout with weights 3-4 days per weights. Wonder what else I can supplement. Thanks for a great video.

  4. I have been an avid viewer of Physionics for quite a while. Nicolas has given me such understandable content about molecular biology that I actually purchased a textbook to help me study the concepts in greater detail. Thank you Dr. Lyon for interviewing Nicolas! Hopefully more people will be introduced to the remarkable work of this humble scientist.

  5. I help people who can't do their activities of daily living get services like caregiving or personal care services. I have been in this field a long time. After following This podcast for awhile now, I have started asking some of these people more or less when things got difficult or when they started needing more help. Most of these people are older but I really do want to know from them. I've had people tell me that it happened really suddenly where they had no strength one day and started feeling tired. I have had some individuals tell me it was indeed after a surgery via spinal or hip where they found they never regained their muscle strength. I've also had some tell me I used to exercise all the time and be thin and then suddenly gain weight. There is definitely a lack of muscle in alot of these individuals but I do feel like some of them, just didnt see it coming. Thank you for this podcast.

  6. I eat grass fed/grass finished but still take 5g of Creatine. I am not a body builder and I am not worried about being "puffy" in the face. As a person ages and they loose that extra fat, it's also lost in the face. However, it's different from a younger person that can loose weight in the face and not look aged. So, I hope, as I loose more weight, I keep a little puff in the face. No need for fillers. 💉I'm guessing that's how it works but "Physionics" may have the details.

  7. From my experience, grandparents react to aging based on the dynamics of the family and culture. My mom's side of the family does not have that Hispanic culture to it, so my mom's dad, my grandpa, when alive, did not want to be waited on. He was physically active. That can be good and bad, since he passed away while trying to fix his car on the side of the road. He had a heart attack. My grandma, however, on my dad's side of the family comes from a traditional Hispanic culture, where she is supposed to be the matriarch. So, as the caretaker, I scheduled physical therapy for her and she was hurt by that. She did well on the physical therapy, as I knew she would, but there is a fear for older ones of being worked too hard or being abandoned or being disrespected. So, the fact that Nicholas also has a background in psychology is helpful to understand the aging experience. 🧠👴👵

  8. Nicolas who I've listened to at Physionics for quite a while is awesome along with you of course Dr. Lyon. I love the science behind much of the exercise and nutrition information out there. I've been at this for over 50 years as far as researching both diet and exercise which was very hard decades ago because info was hard to come by. You really had to research at different levels. Now, you can find excellent info from real scientists and/or experts who don't have agendas and simply want to find factual answers to the volumes of good and bad info floating around the internet

  9. Thank you for the great episode Dr. Lyon! I would love it at some point if you could address whether oral hyaluronic acid supplementation for skin health should be high or low molecular weight. This seems to differ between products, and I can't for the life of me seem to find any sort of consensus online. Thank you!

  10. I have been a Physionic subscriber for quite while and, I still watch your channel. Nic exactly described a major part of my personal philosophy for my life and, the remainder of it. I am 60. My primary goal, with my wife, is to be able do whatever we want, whenever we want without being limited by my physical capacity until the end. We workout 6-7 days/wk, including our sports. My son initiated us to interior rock climbing last year. My limitations were and still are my technique and, not strength and endurance. At 60 and older, we can workout hard and still building strength and endurance to mitigate the aging effect.

  11. This s is the best interview with one of the best source on social media I have watched. That is the reason I subscribe to your channel. Thank you.

  12. 11:17 and Im tuning OUT of this podcast. Second AD within 11 minutes. I will find a podcast that doesn’t force me to pull put my phone 7 times to skip through ADS. Too bad because the information is great but my time is more valuable.

  13. So glad to see Nicolas getting more exposure. A selfish part of me wants to keep his audience small because I feel like he is a hidden gem now. But he is clearly going places! Good for him and thanks for putting him on.

  14. Where can I get the oral hyauloronic acid you were discussing on your podcast? You’ve been the best thing for me, my life has improved and I just discovered you!!! Thanks so much!

  15. Love this topic abt the nerve cells and muscle cells and how deeply connected they are especially a main nerve/neutron that controls multiple muscles. After experiencing shingles a few weeks ago on my left posterior chain, I had suffered muscle atrophy after one week of excruciating pain. Totally makes sense. Thank you @drgabriellelyon

  16. A Balance Component and/or demanding Resonance with an impliment that is oscilating or changing vector rapidly is a key way to achieve Neurological enhancement. Of course the basic Power stuff where speed under load is emphasized like with bands and chains is good also. Alternating cossack lunges while Kettlebell alt Overhead Press ala Steve Cotter is the ultimate. Other examples , one leg deadlift, Nunchuck practice, Overhead Kettlebell Windmill, Bofyblade etc… are majority emphasis on Neurological function because the nerves are working in 2 ways not only firing the various muscles but feedback must be gathered on the changing vector of the impliment or our posture in realtime in order to maintain the resonance with the impliment used or to prevent falling over which adds adrenaline since danger is a component there. As we age this should be priority. THANKS

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