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Here Dr Sorrentino introduces trigonelline a methylated form of nicotinic acid which can boost NAD levels. He also talks about his work at Singapore and the translation of longevity science into the clinic.
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⏲️Chapters
00:00 Introduction to Dr Sorrentino
01:50 Translation from lab to clinic
05:50 How to tailor interventions
08:00 Singapore longevity framework
11:30 Trigonelline
14:50 Trigonelline metabolism
18:30 cf. Nicotinic acid
19:30 Raising NAM
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Dr Sorrentino’s page at NUS
Vincenzo Sorrentino is an Italian-born scientist in the fields of aging, mitochondrial biology and neuromuscular degeneration. He obtained his PhD Cum Laude at the University of Amsterdam on LDL-cholesterol regulation by the ubiquitin-proteasome system. Subsequently, he moved to Lausanne, Switzerland, for his postdoctoral research in Prof. Johan Auwerx’s lab at the EPFL. His work there focused on the understanding of mitochondria and NAD+ metabolism in neurodegeneration and muscle aging. He then obtained a position as Group Leader at the Nestlé Institute of Health Sciences in Lausanne, to lead research focused on integrating basic discoveries on nutraceuticals and their effects on mitochondria and protein homeostasis with their translation into novel clinical applications. Since December 2022, he is an Assistant Professor at the NUS with the Dept. of Biochemistry and the Healthy Longevity TRP, Yong Loo Lin School of Medicine, to continue to develop his research on how metabolism, nutrition and proteostasis are linked and impact on health and aging.
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#NAD #trigonelline #nr
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Another great reason to consume Coffee. Trigonelline should be even contained in decaffeinated coffee. (As a zwitterion it should be barely soluble in organic solvents)
Great information!
15:13 interesting that this works through the Preiss Handler pathway. NMN & NR use the salvage pathway. It's still an open question, though, whether raising NAD levels provides any health benefit. It seems like it would, but the clinical trials haven't shown much. Maybe they don't know what to look for. Great new format with the live interviews, by the way. Since your guests are from all over the world, it might be hard to maintain.
I'd much rather just here the science, rather than a large explanation of the scientists background
Thx Richard for these valuable infos.Would be intresting to have more on this topic.
25% Vulcan 75% Italian…….
Great interview, I became a fans of Dr Sorrentino! will follow his works from now on, thank you Richard!
Richard, another great guest. Singapore now seems another blue zone and maybe why so many brilliant scientists related to aging are moving there.
Thanks Richard.
In the IKON TRIAL COPD is targeted with NR (Nicotinamide Riboside).
Is there a good chance that Trigonelline can be used for COPD patients?
One more way to keep NAD+ up and skip all the NMN and NR hype and expense. I recently learned that coffee ( I drink 3 cups of decaf/d) was high in trigonelline (prior presentation by Vincenzo). Also eat other plant foods high in trig. Turns out in testing my blood my trigonelline level (fasting) my level is about 3 times normal (1.5 micromolar per two tests vs about 0.5 micromolar normal plasma level). Haven't correlated to NAD+ level yet however I exercise and do TRE daily which also helps keep NAD+ up among other benefits. Diet and exercise.
Great interview and it’s great to hear he is working with Brian Kennedy