Anti-Cancer Power of Metformin: How Does it Fit in the Treatment Plan?

The video summarizes the evidence that shows Metformin can play an impactful role in the cancer treatment plan. Specifically, how it can help starve cancer as a component within a metabolic cancer therapy. We explore the research and known mechanisms of action that explain how Metformin has been shown to reduce cancer risks, improve treatment outcomes, disrupt cancer cell growth, and kill cancer cells.

Metformin is considered a game-changer – accessible, cost-effective, and supported by years of research. Don’t miss this empowering insight.

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📚 📚 Links to studies and articles referenced in the video:
Metformin Cancer Treatment search on PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=metformin+cancer+treatment
Five studies showing 26% to 88% reduction in cancer mortality: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0033411
Metformin increases overall survival in stage IV cancer patients: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275681
Metformin inhibits mitochondrial functions, disrupts cell cycle, and inhibits enzymes used by cancer: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04263-8#:~:text=Metformin%20inhibits%20mitochondrial%20complex%20I,on%20Rag%20GTPases%20or%20REDD1.
Metformin triggers apoptosis in cancer cells via endoplasmic reticulum (ER) stress, low glucose may enhance: https://pubmed.ncbi.nlm.nih.gov/30760281/
Cancer cells over express insulin receptor: https://erc.bioscientifica.com/view/journals/erc/18/4/R125.xml
Metformin may also exhibit anti-cancer activity by reducing circulating glucose and insulin levels: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-023-04263-8#:~:text=Indirect%20effects%20of%20metformin,(IGF%2D1)%20levels.
Metformin enhances antitumor activity of T cells: https://pubmed.ncbi.nlm.nih.gov/32221038/
Metformin preferentially kills cancer stem cells: https://www.nature.com/articles/srep00362
2019 review — https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497052/
2023 discussion — https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6497052/
Phase II observed effects against cancer stem cells: https://insight.jci.org/articles/view/133247
Observed increased survival in Stage IV cancer patients who take Metformin: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0275681

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OUTLINE
0:00 Intro
0:12 Role of Metformin Beyond Diabetes
1:51 Metformin’s Anti-Cancer Capabilities
2:58 Mechanisms of Action of Metformin
6:21 Metformin in Cancer Therapy

❗️Medical Advice Disclaimer:
The information, including but not limited to, text, graphics, images and other material contained in this video are for information purposes only and was based on the latest research accessible to the creators at the time of publication. No material in this video is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new healthcare regiment, and never disregard professional medical advice or delay in seeking it because of something you have seen or read in this video or video description. Information provided by the host of the video or the use of any products or services mentioned does not create a practitioner-patient relationship between you and any person affiliated with this production.

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