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Here Dr Seranova talks through her latest paper on the impact of NAD precursors (NR & NMN) on autophagy in human neurons.
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Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.
⏲️Chapters
00:00 Background and the founding of NMN Bio
06:37 Creating autophagy deficient neurons
10:00 Deficiency in autophagy & neuro degeneration
11:20 metabolic dysregulation
13:25 NAD dysfunction
16:30 Impact on mitochondria
18:15 Rescued with NAD precursor
20:30 Sirtuins & PARPS
25:40 Implications for brain health
????Links in this video
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
https://www.sciencedirect.com/science/article/pii/S2211124723003832
Autophagy promotes cell survival by maintaining NAD levels
https://pubmed.ncbi.nlm.nih.gov/36413951/
Nicotinamide mononucleotide improves the Alzheimer’s disease by regulating intestinal microbiota
https://sciencedirect.com/science/article/abs/pii/S0006291X23006538
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease
https://pubmed.ncbi.nlm.nih.gov/28330719/
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#NMN #NAD #autophagy
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