Here Dr Seranova answers some questions on the paper from the first interview (https://youtu.be/fsuhtgKUZRg). Particular topics we discuss, mitochondria fragmentation, de novo pathway in neurons, difference between NR & NMN.
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Dr. Seranova is a serial entrepreneur, holds an MSc in Translational Neuroscience from the University of Sheffield and a PhD in Stem Cell Biology and Autophagy from the University of Birmingham, UK.
⏲️Chapters
00:00 Mitochondrial fragmentation
02:02 De novo pathway in neurons
05:50 NMN & NR comparison
07:50 Inhibiting PARPs and Sirtuins
08:25 Would NMN rescue autophagy?
10:50 Getting NMN into the brain
13:20 Follow on study
????Links in this video
NMN Bio website: https://nmnbio.co.uk/
NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
https://www.sciencedirect.com/science/article/pii/S2211124723003832
Autophagy promotes cell survival by maintaining NAD levels
https://pubmed.ncbi.nlm.nih.gov/36413951/
Nicotinamide mononucleotide improves the Alzheimer’s disease by regulating intestinal microbiota
https://sciencedirect.com/science/article/abs/pii/S0006291X23006538
Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease
https://pubmed.ncbi.nlm.nih.gov/28330719/
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#NMN #NAD #autophagy
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