http://www.DoctorsToTrust.com
presents episode 455 | Dr Thomas Seyfried
Dr Paul Mason podcast
Cells should not continue to produce fermentation when
-oxygen is present
-should shift back to oxidative phosphorylation
If each cancer cell has a different genetic signature…
-all cells in tumor have different genetic mutations
-but, ALL CELLS in
tumor have ONE
COMMON
PHENOTYPE
-it makes sense to
TARGET THE ONE
PHENOTYPE
mSLP: mitochondrial substrate level phosphorylation
-published in
ASN Neuro Journal
-glutamine
-glutamate
-a-Ketoglutarate
-succinyl-CoA
-succinate
~generates a
large amount of
ATP
ATP is coming from a different site in the cancer mitochondria…
-than it does in the normal mitochondria
Left: mitochondria in normal cells;
Right: glioblastoma cancer mitochondria
Cristae contain proteins, lipids (fats) and enzymes allowing
energy creation through oxidative phosphorylation
If the structure of the organelle is abnormal, the
function of the organelle will be abnormal
if the organelle parts responsible for oxidative phosphorylation
are missing, the organelle will be unable to generate energy
through oxidative
phosphorylation
The GBM organelle
in this tumor cell
is abnormal
Same phenomenon in mitochondria of all kinds of cancers…
-breast cancer and colorectal cancer
-disorganized and missing cristae
“We have found
these types of
abnormalities in
all kinds of cancers”
-bladder
-lung
-brain
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paulmason youtube channel
Original Youtube: https://youtu.be/RyB3VI0vwKA
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