#mtor #davidsabatini #mitochondria #MIT #healthspan
In this video Dr. Sabatini discusses his recent paper and in particular how the health of the mitochondria impact the activation of mTOR and how this is signaled.
Dr. David Sabatini is an American scientist and Professor of Biology at the Massachusetts Institute of Technology as well as a member of the Whitehead Institute for Biomedical Research. He is known for his important contributions in the areas of cell signaling and cancer metabolism, most notably the discovery of mTOR, more than 20 years ago. Since then Dr. Sabatini has continued to work on better understanding this complex regulator of our metabolism
Some key references.
The paper discussed in the video.
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
https://www.biorxiv.org/content/10.1101/2020.10.22.351361v1.full.pdf
Twenty-five years of mTOR: Uncovering the link from nutrients to growth
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5692607/
mTOR introduction YouTube Series with Dr. Sabatini
source
